China Cardiac Markers manufacturers Cardiac troponin I/creatine kinase isoenzyme/myoglobin triplex (CTnI/MYO/CK-MB) Test Kit(Fluorescence Immunoassay)
Application
It is suitable for quantitative detection of cardiac troponin I (cTnI) in human serum, plasma or whole blood samples in vitro.
Package
1 test/kit, 5 tests/kit, 10tests/kit,25 tests/kit, 50 tests/kit.
Glossary
The main markers of myocardial injury are troponin T (troponinT), troponin I (troponinI), creatine kinase isoenzyme mass (CK-MBmass) and myoglobin (myoglobin). Troponin is composed of 3 subunits, each of which has an independent structure and different regulatory functions. Cardiac troponin mediates the interaction between actin and myosin under the participation of calcium ions, thereby maintaining the cardiac muscle. relaxation and contraction. When the myocardial cell membrane is intact, cardiac troponin will not penetrate the cell membrane and enter the blood circulation. Only when the myocardial cell membrane is damaged, can troponin be released into the blood. The concentration of troponin in the blood circulation is proportional to the procedure of myocardial damage, and has a half-life of up to 15 days, which is the best indicator for retrospective detection.
Clinical Significance
1. Myocardial infarction occurs within 12 hours
2. Myocardial infarction more than 12 hours from the first onset
3. Myocardial infarction can be basically determined
4. Early muscle or myocardial injury, continuous monitoring of cTnT for 4-8h is recommended
5. There is no myocardial infarction, if it is still suspected, it can be continuously monitored within 2-4 hours
Components:
The kit consists of cardiac troponin I detection reagent card, ID card, buffer solution, instruction manual, desiccant, and aluminum foil bag.
Cardiac troponin I/creatine kinase isoenzyme/myoglobin triplet (CTnI/MYO/CK-MB)
Troponin is composed of three subunits of troponin I, T, and C, which together with tropomyosin regulate
2 regulates actin and myosin interactions by the activity of striated actin ATPase. After myocardial injury, cardiac troponin complexes are released into the blood and begin to rise in the blood after 4-6 hours. The elevated troponin I can remain in the blood for 6-10 days, providing a longer The detection period of cardiac troponin I (cTnI) has a high degree of myocardial specificity and sensitivity, so it has become an ideal myocardial infarction marker.
Creatine kinase (CreatineKinase, CK) has four isoenzyme forms: muscle type (MM), brain type (BB), hybrid type (MB) and mitochondrial type (MiMi), among which MB type mainly exists in cardiomyocytes . During myocardial infarction, creatine kinase increases within 6 hours of onset, peaks within 24 hours, and returns to normal within 3-4 days. Among them, creatine kinase isoenzyme CK-MB has high diagnostic specificity, so it has become the current marker of myocardial infarction. one of the things.
Myoglobin (Myo) is a binding protein composed of a peptide chain and a heme prosthetic group, and is a protein that stores oxygen in muscles. Elevations can occur as soon as 2 hours after the onset of chest pain: patients with severe congestive heart failure and cardiac surgery can also increase due to myocardial damage. Myoglobin is a sensitive indicator for the diagnosis of acute myocardial infarction, so myoglobin has become one of the current markers of myocardial infarction.
Myoglobin reference value
Male 20~80渭g/L;
Female 10~70渭g/L;
Diagnostic limit: >100渭g/L.
Serum Mb levels vary with age, sex, and race, with blacks having higher Mb levels than whites.
"Three items of myocardial infarction" (troponin, creatine kinase isoenzyme, myoglobin) are currently recognized as the best markers of myocardial injury, and are useful for diagnosing myocardial infarction, evaluating the effect of thrombolytic therapy, evaluating re-embolization or embolization Both the scope and the degree of danger are significant.China Cardiac Markers manufacturers
website:http://www.modaivds.com/all-poct-products/cardiac-markers/
